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The Brain Benefits of Creatine

The Brain Benefits of Creatine

Written By: Janette Bell CNP 

 

Last month, a friend told me she started taking creatine — not for the gym, but because she heard it might help with mental energy and focus. At first, I was skeptical. Creatine has always been the “muscle supplement,” right? 

But as I looked into the research, I was surprised by what I found: creatine isn’t just for athletes anymore. Scientists are now exploring how it may support brain health, memory, and mental clarity, and the findings are pretty exciting. 

If you’ve ever wished for a little more brain power especially on those busier, low sleep days, consider looking into this supplement! Research suggests that creatine may help your brain maintain efficiencies, even when you are tired!6,7 


Why Creatine Isn’t Just for Muscles 

Creatine helps the body make ATP — the quick energy your cells use to function. We usually connect this to strength and performance, but here’s the fun twist: 

Your brain uses a massive amount of energy every single day.¹,³ 

Which means creatine may help support: 

  • Memory and learning 

  • Focus and concentration 

  • Quick thinking and problem-solving 

Think of creatine as an energy reserve for your muscles and for your mind too 

 

What Research Is Showing So Far 

Memory & Mental Processing 

One area of research that gets a lot of attention is creatine’s potential to support memory and brain processing speed.

A 2024 review found that creatine may support memory, attention, and how quickly we process information. ⁴

Another 2024 analysis also noted improvements specifically in memory and attention speed.⁵

In simple terms: creatine may help your brain “fire” a little faster when you need it. 


When You're Low on Sleep or Mentally Drained 

We all know the foggy feeling after a short night’s sleep. Whether from parenting, stress, shift work, or just life happening.

Studies show that creatine may help maintain mental performance when you’re tired. ⁶, 
Some people describe it as feeling a bit more alert, clear, or “switched on” during mentally demanding days.

It’s not a substitute for rest, but it may help your brain cope better when sleep isn’t great. 


Supporting Brain Health as We Age 

As we age, our body and brain naturally go through changes — including how efficiently we produce cellular energy.

Emerging research suggests creatine may support memory and attention in older adults, helping maintain cognitive function as we age. ⁸

Even better: combining creatine with light strength training appears to be especially beneficial for healthy ageing - body and mind. ⁹ 


Vegans & Vegetarians May Notice a Bigger Difference 

Creatine is naturally found in meat and fish. Those who have a planet-based diet may exhibit lower levels within the brain. So, if you eat a mostly plant-based diet, creatine levels may be lower including in the brain.

Research shows that vegans and vegetarians may see even greater cognitive benefits when supplementing with creatine. ¹ 


How to Add Creatine to Your Daily Routine 

If you’re curious about trying creatine, the most researched and widely used form is creatine monohydrate.

Here’s how simple it can be: 

  • Daily amount: 3–5 g per day (often one scoop). ¹³ 

  • When to take it: Anytime! Morning, afternoon, or evening — consistency matters more than timing. 

  • How to take it: Mix into water, smoothie, juice, or your protein shake. 

Some people choose to do a short “loading phase” by taking more for a few days to saturate muscles faster, but this is optional. ¹³ 

Helpful Tips 

  • Drink water throughout the day, as creatine draws water into muscle cells. ¹³ 

  • Take it daily for best results — the benefits come from consistent use. 


What You May Notice 

Everyone’s experience is different, but here’s what many people report: 


Physical benefits 

  • Better strength and workout performance 

  • More energy for movement 

  • Support for lean muscle over time¹³–¹⁴ 

Whole-body wellness benefits 

  • Feeling more clear-minded during busy or tiring days 

  • Better focus and concentration 

  • More mental resilience when sleep isn’t ideal 

  • Support for memory and brain processing 


Is Creatine Safe? 

Creatine is one of the most well-studied supplements in the world, and research supports its safety when used as recommended. ¹³,¹

As with any supplement, if you are pregnant, breastfeeding, have a medical condition, or take medication, check with your healthcare provider before adding it to your routine. 


Final Thoughts 

Creatine will always have its place in fitness and performance — but the emerging research around brain health, mental energy, and cognitive support is giving people a new reason to love it.

If you’re looking for one simple supplement that may support both your body and your brain, creatine is a compelling option to consider as part of a healthy lifestyle. 


References 

¹ Avgerinos, K. I., et al. (2018). Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Psychopharmacology, 235(8), 2235–2247. https://doi.org/10.1007/s00213-018-4955-2 

² Rae, C., et al. (2003). Oral creatine supplementation improves brain performance: A double-blind, placebo-controlled study. Proceedings of the Royal Society B: Biological Sciences, 270, 2147–2150. https://doi.org/10.1098/rspb.2003.2492 

³ Sandkühler, J. F., et al. (2023). Effects of creatine supplementation on cognitive performance: A randomized controlled study. BMC Medicine, 21, 418. https://doi.org/10.1186/s12916-023-03146-5 

⁴ Xu, C., et al. (2024). The effects of creatine supplementation on cognitive function in adults: A systematic review and meta-analysis. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2024.1424972 

⁵ Xu, C., et al. (2024). The effects of creatine supplementation on cognitive function in adults (meta-analysis data). Frontiers in Nutrition. https://www.frontiersin.org/articles/10.3389/fnut.2024.1424972/full 

⁶ McMorris, T., et al. (2006). Effect of creatine supplementation and sleep deprivation on cognitive and psychomotor performance. Psychopharmacology, 185, 93–103. https://doi.org/10.1007/s00213-006-0297-7 

Gordji-Nejad, A., et al. (2024). Single-dose creatine improves cognitive performance and brain energy during sleep deprivation. Scientific Reports, 14, 33138. https://doi.org/10.1038/s41598-024-54249-9 

⁸ Marshall, S., et al. (2025). Creatine and cognition in aging: A systematic review. Nutrition Reviews. https://doi.org/10.1093/nutrit/nuaf135 

⁹ Bonilla, D. A., et al. (2024). The power of creatine plus resistance training for healthy aging. European Geriatric Medicine. https://doi.org/10.1007/s41999-024-01068-2 

¹⁰ Benton, D., & Donohoe, R. (2011). The influence of creatine supplementation on cognitive functioning of vegetarians and omnivores. British Journal of Nutrition, 105, 1100–1105. https://doi.org/10.1017/S0007114510004733 

¹³ Antonio, J., et al. (2021). Common questions and misconceptions about creatine supplementation. Journal of the International Society of Sports Nutrition, 18, 13. https://doi.org/10.1186/s12970-021-00412-w 

¹⁴ Kreider, R. B., et al. (2017). International Society of Sports Nutrition position stand: Safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. https://doi.org/10.1186/s12970-017-0173-z